Abstract
Hydrogen Sulfide (H(2)S), an endogenously produced gasotransmitter, is involved in various important physiological and disease conditions, including vasodilation, stimulation of cellular bioenergetics, anti-inflammation, and pro-angiogenesis. In cancer, aberrant up-regulation of H(2)S-producing enzymes is frequently observed in different cancer types. The recognition that tumor-derived H(2)S plays various roles during cancer development reveals opportunities to target H(2)S-mediated signaling pathways in cancer therapy. In this review, we will focus on the mechanism of H(2)S-mediated protein persulfidation and the detailed information about the dysregulation of H(2)S-producing enzymes and metabolism in different cancer types. We will also provide an update on mechanisms of H(2)S-mediated cancer progression and summarize current options to modulate H(2)S production for cancer therapy.