Precision medicine exploration of postpartum rectus abdominis muscle separation: from basic research to clinical practice

产后腹直肌分离的精准医学探索:从基础研究到临床实践

阅读:1

Abstract

Postpartum diastasis recti abdominis (PDRA), characterized by pathological separation of the rectus abdominis muscles, affects 30%-60% of women, with many cases persisting beyond 6 months postpartum and having significant impacts on musculoskeletal function and quality of life. This review synthesizes recent advancements across molecular pathogenesis, precision diagnostics, and therapeutic innovations. Key findings reveal that PDRA pathophysiology involves pregnancy-induced hormonal fluctuations, extracellular matrix remodeling, and mechanical overloading, necessitating individualized management. Artificial intelligence (AI)-enhanced ultrasonography achieves superior diagnostic accuracy (Dice score: 85.93%, r = 0.944 vs. manual measurements) over traditional methods, while minimally invasive techniques including laparoscopic "Slim-Mesh" repair demonstrate reduced recurrence rates (< 10%) and enhanced recovery compared to open surgery. Biomaterial integration (such as synthetic and bioabsorbable meshes) promotes anatomical reconstruction. Intelligent rehabilitation systems combining surface electromyography and wearable sensors improve inter-rectus distance (IRD) reduction through real-time biomechanical feedback. Critical challenges persist regarding the lack of standardized diagnostic criteria, long-term outcome validation of emerging technologies (> 5-year follow-up gaps), and optimization of AI-driven predictive models. We propose a potential precision medicine framework that integrates dynamic imaging, molecular profiling, and patient-specific interventions to optimize functional recovery and address heterogeneity in PDRA management.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用;引用内容仅为补充信息,不代表本站立场。

2、若认为本页面引用内容涉及侵权,请及时与本站联系,我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容,需注明“来源:[生知库]”并获得授权;使用引用内容的,需自行联系原作者获得许可。

4、投稿及合作请联系:info@biocloudy.com。