Abstract
OBJECTIVE: The purpose of this study was to compare long-term survival outcomes of simple hysterectomy versus radical hysterectomy in stage IA2 cervical cancer. METHODS: A total of 440 patients who underwent simple hysterectomy (SH group) or radical hysterectomy (RH group) between 2014 and 2019 were included in this study. Overall survival (OS) and disease-free survival (DFS) were analyzed using the Kaplan-Meier method and compared by the Log rank test. The Cox proportional hazards regression model was employed to control for confounders. RESULTS: There were 258 patients in the RH group and 182 patients in the SH group. The two groups had similar 5-year DFS rate (89.25% vs 91.14%, P=0.562) and 5-year OS rate (95.71% vs 94.76%, P=0.482). Multivariable analysis showed that simple hysterectomy was not independently associated with poorer DFS (aHR, 1.608; 95% CI, 0.640-4.041; P=0.312) and OS (aHR, 1.122; 95% CI, 0.319-3.493; P=0.858) than radical hysterectomy for women with stage IA2 cervical cancer. CONCLUSION: For stage IA2 cervical cancer, a simple hysterectomy is safe and effective. Further studies are needed to testify against our findings.