C/EBPα-dependent preneoplastic tumor foci are the origin of hepatocellular carcinoma and aggressive pediatric liver cancer
C/EBPα 依赖性癌前肿瘤灶是肝细胞癌和侵袭性儿童肝癌的起源
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作者:Ashley Cast, Leila Valanejad, Mary Wright, Phuong Nguyen, Anita Gupta, Liqin Zhu, Soona Shin, Nikolai Timchenko
| 期刊: | Hepatology | 影响因子: | 12.900 |
| 时间: | 2018 | 起止号: | 2018 May;67(5):1857-1871. |
| doi: | 10.1002/hep.29677 | 方法学: | FCM、IF、IHC-P、WB |
| 靶点: | FETA | 研究方向: | 肿瘤 |
| 疾病类型: | 肝癌 | 细胞类型: | 其它细胞 |
Conclusion
The earliest steps of adult HCC and aggressive pediatric liver cancer have identical features that include conversion of the tumor suppressor C/EBPα into an oncogenic isoform, which further creates preneoplastic foci where hepatocytes dedifferentiate into cancer cells, giving rise to liver cancer. (Hepatology 2018;67:1857-1871).
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