Abstract
OBJECTIVE: This study aims to investigate whether the inflammatory indexes including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and systemic inflammatory indexes (SIIs) can prognosis the outcome of patients with severe traumatic brain injury (sTBI). METHODS: A total of 118 sTBI patients were retrospectively recruited from June 2015 to June 2024. First, the clinical data including baseline clinical features, hematological indexes at 1/3/7 days after hospital admission, were collected, and the Glasgow Coma Scale (GCS) at 3 months after discharge was recorded. Then, the absolute value of SII, NLR, PLR and LMR was calculated, and the prognostic value of them was further analyzed via comparative, relevant, and regression statistical methods. RESULTS: Compared to sTBI patients in the favorable outcome group, the absolute value of white blood cell (WBC) and neutrophil at 1/3/7 days, and the absolute value of monocyte at 1 day and NLR at 3 days after admission was higher in sTBI patients of the unfavorable outcome group. ROC curve and multivariate logistic regression analysis indicated that NLR at 3 days after admission was an independent prognostic factor for GOS in patients with sTBI. CONCLUSIONS: NLR at 3 days after admission might be a new, accurate, and objective inflammatory index, which had prognostic value in the clinical outcome prediction for patients with sTBI.