Abstract
INTRODUCTION: In humans, satisfying sexual activity within a pair-bond plays a significant role in relationship quality and maintenance, beyond reproduction. However, the neural and genetic correlates for this basic species-supporting function, in response to a pair-bonded partner, are unknown. METHODS: We examined the neural correlates of oxytocin- (Oxtr rs53576) and vasopressin- (Avpr1a rs3) receptor genotypes with sexual satisfaction and frequency, among a group of individuals in pair-bonds (M relationship length = 4.1 years). Participants were scanned twice (with functional MRI), about 1-year apart, while viewing face images of their spouse and a familiar, neutral acquaintance. RESULTS: Sex satisfaction scores showed significant interactions with Oxtr and Avpr variants associated with social behaviors in a broad network of regions involved in reward and motivation (ventral tegmental area, substantia nigra [SN], and caudate), social bonding (ventral pallidum), emotion and memory (amygdala/hippocampus), hormone control (hypothalamus); and somatosensory and self-other processing (SII, frontal, and temporal lobe). Sexual frequency interactions also showed activations in the SN and paraventricular hypothalamus for Avpr, and the prefrontal cortex for Oxtr. CONCLUSIONS: Satisfying sexual activity in pair-bonds is associated with activation of subcortical structures that support basic motivational and physiological processes; as well as cortical regions that mediate complex thinking, empathy, and self-other processes highlighting the multifaceted role of sex in pair-bonds. Oxtr and Avpr gene variants may further amplify both basic and complex neural processes for pair-bond conservation and well-being.