Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs

MYC 旁系同源物的染色体外 DNA 扩增导致小细胞肺癌获得性交叉耐药

阅读：6

作者：Shreoshi Pal Choudhuri, Luc Girard, Jun Yi Stanley Lim, Jillian F Wise, Braeden Freitas, Di Yang, Edmond Wong, Seth Hamilton, Victor D Chien, Yoon Jung Kim, Collin Gilbreath, Jun Zhong, Sarah Phat, David T Myers, Camilla L Christensen, Hanieh Mazloom-Farsibaf, Marcello Stanzione, Kwok-Kin Wong, Yin

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2024

起止号：

2024 May 1;14(5):804-827.

doi：

10.1158/2159-8290.CD-23-0656

研究方向：

肿瘤

疾病类型：

肺癌

细胞类型：

其它细胞

Significance

SCLC is initially chemosensitive, but acquired cross-resistance renders this disease refractory to further treatment and ultimately fatal. The genomic drivers of this transformation are unknown. We use a population of PDX models to discover that amplifications of MYC paralogs on ecDNA are recurrent drivers of acquired cross-resistance in SCLC. This article is featured in Selected Articles from This Issue, p. 695.

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