Results from patient-derived xenograft models support co-administration of allopurinol and 6-mercaptopurine to reduce hepatotoxicity and improve event-free survival in pediatric acute lymphoblastic leukemia

来自患者来源的异种移植模型的结果支持在儿童急性淋巴细胞白血病中联合使用别嘌醇和6-巯基嘌呤，以降低肝毒性并提高无事件生存期。