Abstract
BACKGROUND: In the Koutiala region of Mali, preventing and effectively treating klebsiella pneumoniae infections children aged 0 to 59 months requires ongoing clinical research. Klebsiella pneumoniae is an enterobacteria responsible for many serious infections such as pneumoniae, especially nosocomial. Antibiotic resistance is a major problem and presents a challenge for the treatment of K. pneumoniae infections. OBJECTIVES: To study the antibiotic resistance phenotypes of K. pneumoniae 2024. METHODS: Human blood and urine samples were received and grown in the laboratory to isolate strains and determine resistance phenotypes RESULTS: On the 2771 samples treated during our study, there were 623 positive or 22%. The most frequently found germs in the blood and urine were Escherichia coli, Salmonella spp., K. pneumoniae and Streptococcus pneumoniae. The distribution of K. pneumoniae strains 4% (25 strains) for positive samples. That is 64% in the blood and 36% in the urine. The number of isolated strains of K. pneumoniae was in favour of the male sex with 56% and 44% for the female sex. The number of isolate strains of K. pneumoniae was 64% for infants, 32% for children, and 4% for newborns. The services that recorded the most strains were the nutrition services and hospital paediatrics. For the future of patients 12% died during our study. Regarding antibiotic resistance, there was ampicillin, the combination trimethoprim+ sulfamethoxazole, ceftriaxone, amoxicillin + clavulanic acid, cefoxitin; aztreonam and cefepime. The most sensitive antibiotics were amikacin, cefotaxime, ertapenem and meropenem. CONCLUSIONS: This study showed that 25 strains of K. pneumoniae were isolated, including 20 strains of BMR among which there were 15 strains of BLSE and 5 strains of suspected carbapenemases.