A rare case of a primary atrial myxoma with metaplastic ossification and its multimodal imaging features

INTRODUCTION: Cardiac myxomas are rare, benign intracardiac tumors that arise from pluripotent mesenchymal stem cells. The vast majority of myxomas consist of mesenchymal stem cells suspended within a mucoid, gelatinous material. PRESENTATION OF CASE: A 55-year-old woman presented with progressive chest pain due to a left atrial myxoma with unusual calcification. A complete resection was performed and pathology confirmed the diagnosis of myxoma with metaplastic ossification. DISCUSSION: This case represents the diagnostic challenges of atypical myxomas and emphasizes the importance of multimodal anatomic and functional imaging for accurate preoperative assessment. CONCLUSIONS: This case showcases the heterogeneity of cardiac myxomas, the typical natural history, and the value of multimodal imaging in managing these rare intracardiac tumors.