Abstract
INTRODUCTION AND IMPORTANCE: Liposarcoma is one of the most common mesenchymal neoplasms in adults. Among liposarcomas, gastrointestinal tract involvement is uncommon, and liposarcoma of the stomach is a particularly rare entity, In addition, few cases of gastric liposarcoma with malignant transformation from benign gastric lipoma have been reported. PRESENTATION OF CASE: Here we present the case of a 62-year-old male patient who was diagnosed with gastric liposarcoma and managed with laparoscopic surgical resection. He was first diagnosed with subepithelial lipoma of the stomach 4 years ago and was under observation, but underwent laparoscopic distal gastrectomy due to malignant transformation of gastric lipoma. He has been following up for 1 year after surgery, and there are no recurrence or other complications to date. CLINICAL DISCUSSION: This patient was initially diagnosed with gastric lipoma and was surgically resected after 4 years of observation to show malignant transformation. To the best of our knowledge, this case represents the first report of gastric lipoma demonstrating malignant transformation into gastric liposarcoma. CONCLUSION: Gastric lipoma can be transformed into gastric liposarcoma, so if the size is large or the rate of size change is fast, surgical resection is recommended in the early state, and en-bloc resection including node dissection and reconstruction are desirable during surgery.