Abstract
Hepatic cysts are common benign liver lesions that usually remain stable, with spontaneous regression considered uncommon and slow. Novel non-invasive approaches that may favorably influence cyst resolution warrant exploration. We report a 75-year-old woman with a 4.8 cm cystic-solid lesion in hepatic segment IV identified during routine screening. The patient did not meet the criteria for interventional management but expressed psychological concern regarding disease progression. She underwent compensating bio-information energy (CBE) modulation, an approach using plant-derived ultra-weak photon emissions intended to promote physiological regulation, over an approximately eight-week period. Serial ultrasonography demonstrated progressive lesion regression, with measurable reduction at 17 days and complete radiological resolution by 10 weeks. No pharmacologic, surgical, or lifestyle interventions occurred concurrently. A 22-week consolidation follow-up confirmed durable resolution without recurrence, and the patient remained asymptomatic. The accelerated and sustained regression of a hepatic cyst temporally associated with CBE modulation contrasts with the slow natural history of spontaneous involution. Although causality cannot be established from a single case, this observation supports further controlled investigation into CBE as a potential non-invasive adjunct for benign hepatic cysts. While causality cannot be inferred from a single uncontrolled observation, this temporally associated regression should be regarded as a hypothesis-generating finding that warrants further investigation under rigorously controlled experimental and clinical conditions.