Abstract
Regulating calcium ion (Ca(2+)) channels to improve the cell cycle and metabolism is a promising technology, ensuring increased cell growth, differentiation, and/or productivity. In this regard, the composition and structure of Ca(2+) channels play a vital role in controlling the gating states. In this review, Saccharomyces cerevisiae, as a model eukaryotic organism and an essential industrial microorganism, was used to discuss the effect of its type, composition, structure, and gating mechanism on the activity of Ca(2+) channels. Furthermore, the advances in the application of Ca(2+) channels in pharmacology, tissue engineering, and biochemical engineering are summarized, with a special focus on exploring the receptor site of Ca(2+) channels for new drug design strategies and different therapeutic uses, targeting Ca(2+) channels to produce functional replacement tissues, creating favorable conditions for tissue regeneration, and regulating Ca(2+) channels to enhance biotransformation efficiency.