Nanopore sequencing of cerebrospinal fluid of three patients with cryptococcal meningitis

三例隐球菌性脑膜炎患者脑脊液的纳米孔测序

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作者:Ke Jin, Xiaojuan Wang, Lingzhi Qin, Yazhen Jia, Keke Zhou, Yusu Jiang, Milan Zhang, Tao Zhang, Mengge Zhang, Weifeng Ma, Lin Jia, Yongshi Teng, Shuhua Dai, Wei Li

Background

Cryptococcal meningitis (CM) has a high morbidity and mortality due to the low detection of Cryptococcus in cerebrospinal fluid (CSF) during the early stage of the disease with traditional

Conclusion

Nanopore sequencing may be useful in assisting with the clinical diagnosis of CM. Further research is needed to determine the sensitivity and specificity of nanopore sequencing of CSF.

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