Abstract
BACKGROUND: Phytosomal curcumin may have some potential in improving anthropometric indices for nonalcoholic fatty liver disease, and this meta-analysis aims to study the effect of phytosomal curcumin on anthropometric indices for nonalcoholic fatty liver disease. METHODS: We have searched several databases including PubMed, EMbase, Web of science, EBSCO and Cochrane library databases, and selected the randomized controlled trials (RCTs) comparing phytosomal curcumin with placebo for nonalcoholic fatty liver disease. This meta-analysis was conducted using the random-effect or fixed-effect model based on the heterogeneity. RESULTS: Seven RCTs were included in this meta-analysis. Compared with placebo in nonalcoholic fatty liver disease, phytosomal curcumin was associated with substantially reduced body mass index (BMI, mean difference [MD] = -0.72; 95% confidence interval [CI] = -1.11 to -0.33; P = .0003), body fat percent (MD = -2.04; 95% CI = -3.10 to -0.98; P = .0002), weight (MD = -2.15; 95% CI = -3.78 to -0.53; P = .01) and waist circumference (MD = -2.09; 95% CI = -4.05 to -0.12; P = .04), but showed no influence on hip circumference (MD = -0.06; 95% CI = -0.59 to 0.47; P = .83) or waist/hip ratio (MD = 0; 95% CI = -0.01 to 0.01; P = 1). CONCLUSIONS: Phytosomal curcumin is effective to improve anthropometric indices for patients with nonalcoholic fatty liver disease.