Abstract
BACKGROUND: The differential impacts of radical prostatectomy (RP) and external beam radiotherapy (EBRT) on sexual health in gay and bisexual men (GBM) with prostate cancer remain understudied, limiting recommendations incorporating preferred sexual behavior. METHODS: Secondary analysis of Restore-2 compared outcomes in GBM after RP (n = 127) or EBRT (n = 27). RESULTS: Compared to RP, EBRT was associated with lower rates of climacturia (11% vs. 59%, p < 0.001), condom-related erectile dysfunction (27% vs. 51%, p = 0.047), and decreased penile length/girth (49% vs. 69%, p = 0.07), but higher rates of anodyspareunia (33% vs. 14%, p = 0.06). CONCLUSIONS: Exploratory findings suggest EBRT for insertive intercourse, RP for receptive intercourse.