Abstract
The crystal structure determination of metal complexes of curcuminoids is a relevant topic to assess their unequivocal molecular structure. We report herein the first two X-ray crystal structures of homoleptic metal complexes of a curcuminoid, namely Dimethoxycurcumin (DiMeOC), with gallium and indium. Such successful achievement can be attributed to the suppression of interactions from the phenolic groups, which favor an appropriate molecular setup, rendering Dimethoxycurcumin gallium ((DiMeOC)(2)-Ga) and Dimethoxycurcumin indium ((DiMeOC)(3)-In) crystals. Surprisingly, the conformation of ligands in the crystal structures shows differences in each metal complex. Thus, the ligands in the (DiMeOC)(2)-Ga complex show two different conformers in the two molecules of the asymmetric unit. However, the ligands in the (DiMeOC)(3)-In complex exhibit three different conformations within the same molecule of the asymmetric unit, constituting the first such case described for an ML(3) complex. The cytotoxic activity of the (DiMeOC)(2)-Ga complex is 4-fold higher than cisplatin against the K562 cell line and has comparable activity towards U251 and PC-3 cell lines. Interestingly, this complex exhibit three times lesser toxicity than cisplatin and even slightly lesser cytotoxicity than curcumin itself.