Buformin increases radiosensitivity in cervical cancer cells via cell-cycle arrest and delayed DNA-damage repair

丁福明通过细胞周期停滞和延迟 DNA 损伤修复增加宫颈癌细胞的放射敏感性

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作者:Ling Chen, Ting Zhang, Qiuli Liu, Mei Tang, Yu'e Yang, Yuan Wang, Haifeng Qiu, Jinjin Yu

Abstract

Our idea originated in the thought of discovering new effects of old drugs. Although this study is a basic research, it is very close to clinical treatment. Flow cytometry and immunofluorescence were used to verify that buformin increases radiosensitivity. We aimed to address one of the thorniest problems in treatment process. Based on discovering new effects of old drugs, it is feasible to use buformin as an anticancer drug in clinical application. This will provide new ideas for clinical treatment.

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