Abstract
Most natural product research is market-driven and thus many plant species are overlooked for their health value due to lack of financial incentives. This may explain the limited information available about the health effects of the edible fruit species Melicoccus bijugatus, a member of the Sapindaceae family that grows mostly in the Caribbean and in parts of South America. However, recent phytochemical studies of these fruits have shed some light on their biological effects. In this review the health effects of M. bijugatus fruit pulp and seeds are assessed in relation to phytochemical and ethnobotanical studies, as well as chemotaxonomic information and medicinal uses of other Sapindaceae species. The chemistry of M. bijugatus fruits was found to be different than the other Sapindaceae fruits, although some of the medicinal uses were similar. Specific phenolics or sugars in M. bijugatus fruits may contribute to their therapeutic uses, especially for gastrointestinal problems, and to some extent toxicological effects. This review focuses our understanding about the specific biological effects of M. bijugatus fruits, which may be useful for predicting other medicinal uses, potential drug or food interactions and may benefit people where the fruits are prevalent and healthcare resources are scarce.