Abstract
INTRODUCTION: We present a theoretical foundation based on the spontaneous self-organized temporal criticality (SOTC) and multifractal dimensionality μ to model complex neurophysiological and behavioral systems to infer the optimal empirical transfer of information among them. We hypothesize that heterogeneous time series characterizing the brain, heart, and lung organ-networks (ONs) are necessarily multifractal, whose level of complexity and, therefore, their information content is measured by their multifractal dimensions. METHODS: We apply modified diffusion entropy analysis (MDEA) to assess multifractal dimensions of ON time series (ONTS), and complexity synchronization (CS) analysis to infer information transfer among ONs that are part of a network-of-organ-networks (NoONs). An automated parameter selection process is proposed that relies on the Kolmogorov-Smirnov statistic to properly choose stripe sizes which are crucial in the MDEA analysis using synthetic duration times derived from the Mittag-Leffler map, shows the strength of KS-based stripe size selection to track changes in the IPL parameter μ . The purpose of this paper is to advance the validation, standardization, and reconstruct-ability of MDEA and CS analysis of heterogeneous neurophysiological time series data. RESULTS: Results from processing these datasets show that the complexity of brain, heart, and lung ONTS co-vary over time during cognitive task performance in 44% of subjects, while complexity of brain-heart interactions significantly co-vary in 85% of subjects. DISCUSSION: We conclude that certain principles, guidelines, and strategies for the application of MDEA analysis need further consideration. We conclude with a summary of the MDEA's limitations and future research directions.