Abstract
Heart valves play a critical role in maintaining proper cardiovascular function in the human heart; however, valve diseases can lead to improper valvular function and reduced cardiovascular performance. Depending on the extent and severity of the valvular disease, replacement operations are often required to ensure that the heart continues to operate properly in the cardiac system. Transcatheter aortic valve replacement (TAVR) procedures have recently emerged as a promising alternative to surgical replacement approaches because the percutaneous methods used in these implant operations are significantly less invasive than open heart surgery. Despite the advantages of transcatheter devices, the precise deployment, proper valve sizing, and stable anchoring required to securely place these valves in the aorta remain challenging even in successful TAVR procedures. This work proposes a parametric modeling approach for transcatheter heart valves (THVs) that enables flexible valvular development and sizing to effectively generate existing and novel valve designs. This study showcases two THV configurations that are analyzed using an immersogeometric fluid-structure interaction (IMGA FSI) framework to demonstrate the influence of geometric changes on THV performance. The proposed modeling framework illustrates the impact of these features on THV behavior and indicates the effectiveness of parametric modeling approaches for enhancing THV performance and efficacy in the future.