Abstract
OBJECTIVE: This study aimed to synthesize existing evidence on preventive interventions for postpartum depression and to explore how this evidence may inform the development of policy-relevant approaches in different healthcare contexts. METHODS: A scoping review of systematic reviews published between 2000 and 2025 was conducted. Forty-four reviews met the inclusion criteria. The review focused on interventions targeting postpartum women and addressing psychosocial, psychological, or biological risk factors for PPD. Expert consultation was used to support the interpretation and contextualization of findings derived from the published evidence. RESULTS: Sixteen preventive interventions were identified, addressing psychosocial, psychological, and biological determinants of postpartum depression. Four policy options emerged: (1) establishing social support systems, (2) empowering women through education and training, (3) providing professional home-visit support, and (4) delivering remote interventions via web- or phone-based platforms. Evidence indicates that these strategies improve maternal well-being, enhance resilience, and reduce depressive symptoms. Challenges include variability in effectiveness, cultural acceptability, and resource requirements. CONCLUSION: Effective PPD prevention requires practical, flexible, and context-sensitive interventions that integrate social, educational, and professional support. Collaboration between policymakers and healthcare providers is essential to implement culturally adapted, evidence-based strategies that promote maternal mental health, improve mother–infant outcomes, and reduce the broader social and economic burden associated with PPD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s44192-026-00371-1.