Genotyping of Mycobacterium tuberculosis: application in epidemiologic studies

结核分枝杆菌基因分型:在流行病学研究中的应用

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Abstract

Genotyping is used to track specific isolates of Mycobacterium tuberculosis in a community. It has been successfully used in epidemiologic research (termed 'molecular epidemiology') to study the transmission dynamics of TB. In this article, we review the genetic markers used in molecular epidemiologic studies including the use of whole-genome sequencing technology. We also review the public health application of molecular epidemiologic tools.

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