Abstract
Fiber tractography enables the in vivo reconstruction of white matter fibers in 3 dimensions using data collected by diffusion tensor imaging, thereby helping to understand functional neuroanatomy. In a pre-operative context, it provides essential information on the trajectory of fiber bundles of medical interest, such as cranial nerves. However, the optimization of tractography parameters is a time-consuming process and requires expert neuroanatomical knowledge, making the use of tractography difficult in clinical routine. Tractogram filtering is a method used to isolate the most relevant fibers. In this work, we propose to use filtering as a post-processing of tractography to avoid the manual optimization of tracking parameters and therefore making a step forward automation of tractography. To question the feasibility of automated tractography of cranial nerves, we perform an analysis of main cranial nerves on a series of patients with skull base tumors. A quantitative evaluation of the filtering performance of two state-of-the-art and a new entropy-based methods is carried out on the basis of reference tractograms produced by experts. Our approach proves to be more stable in the selection of the optimal filtering threshold and turns out to be interesting in terms of computational time complexity.