Background
Gestational diabetes mellitus (GDM) is a disease often manifests in mid to late pregnancy with symptoms including hyperglycemia, insulin resistance and fetal mal-development. The C57BL/KsJ-Lep (db/+) (db/+) mouse is a genetic GDM model that closely mimicked human GDM symptoms. Resveratrol (RV) is a naturally existing compound that has been reported to exhibit beneficial effects in treating type-2 diabetes.
Conclusions
Our findings further supported the potential therapeutic effect of RV on not only diabetes, but also alleviating GDM.
Methods
In this study, we investigated the effect of RV on the pregnant db/+ GDM mouse model, and the underlying molecular mechanism.
Results
RV greatly improved glucose metabolism, insulin tolerance and reproductive outcome of the pregnant db/+ females. Moreover, we found that RV relieved GDM symptoms through enhancing AMPK activation, which in turn reduced production and activity of glucose-6-phosphatase in both pregnant db/+ females and their offspring. Conclusions: Our findings further supported the potential therapeutic effect of RV on not only diabetes, but also alleviating GDM.