Upregulated DNA Damage-Linked Biomarkers in Parkinson's Disease Model Mice
帕金森病模型小鼠中 DNA 损伤相关生物标志物上调
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作者:Fei Zeng, Karsten Parker, Yanqiang Zhan, Matthew Miller, Meng-Yang Zhu
| 期刊: | ASN Neuro | 影响因子: | 3.900 |
| 时间: | 2023 | 起止号: | 2023 Jan-Dec:15:17590914231152099. |
| doi: | 10.1177/17590914231152099 | 方法学: | IHC、WB |
| 研究方向: | 神经 | 疾病类型: | 帕金森 |
Abstract
The present study examined expression of DNA damage markers in VMAT2 Lo PD model mice. The results demonstrate there is a significant increase in these DNA damage markers mostly in the brain regions of 18- and 23-month-old model mice, indicating oxidative stress-induced DNA lesion is an important pathologic feature of this mouse model.
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