Deep phenotyping and genomic data from a nationally representative study on dementia in India

来自印度全国具有代表性的痴呆症研究的深度表型分析和基因组数据

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作者:Jinkook Lee, Sarah Petrosyan, Pranali Khobragade, Joyita Banerjee, Sandy Chien, Bas Weerman, Alden Gross, Peifeng Hu, Jennifer A Smith, Wei Zhao, Leon Aksman, Urvashi Jain, G S Shanthi, Ravi Kurup, Aruna Raman, Sankha Shubhra Chakrabarti, Indrajeet Singh Gambhir, Mathew Varghese, John P John, Himans

Abstract

The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is a nationally representative in-depth study of cognitive aging and dementia. We present a publicly available dataset of harmonized cognitive measures of 4,096 adults 60 years of age and older in India, collected across 18 states and union territories. Blood samples were obtained to carry out whole blood and serum-based assays. Results are included in a venous blood specimen datafile that can be linked to the Harmonized LASI-DAD dataset. A global screening array of 960 LASI-DAD respondents is also publicly available for download, in addition to neuroimaging data on 137 LASI-DAD participants. Altogether, these datasets provide comprehensive information on older adults in India that allow researchers to further understand risk factors associated with cognitive impairment and dementia.

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