Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses

血小板第 4 因子促进登革热和日本脑炎病毒的快速复制和繁殖

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作者:Amrita Ojha, Angika Bhasym, Sriparna Mukherjee, Gowtham K Annarapu, Teena Bhakuni, Irshad Akbar, Tulika Seth, Naval K Vikram, Sudhanshu Vrati, Anirban Basu, Sankar Bhattacharyya, Prasenjit Guchhait

Background

Activated platelets release cytokines/proteins including CXCL4 (PF4), CCL5 and fibrinopeptides, which regulate infection of several pathogenic viruses such as HIV, H1N1 and HCV in human. Since platelet activation is the hallmark of Dengue virus (DV) infection, we investigated the role of platelets in DV replication and also in a closely related Japanese Encephalitis virus (JEV).

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