Abstract
PURPOSE: To explore the effect of the variation of pupil diameter (PD) and intraocular pressure (IOP) induced by femtosecond laser treatment on the subsequent phacoemulsfication and intraocular lens implantation. And whether the application of 0.1% pranoprofen could significantly reduce the miosis and increased IOP caused by femtosecond laser treatment in femtosecond laser-assisted cataract surgery (FLACS). METHODS: In this study, patients were pretreated with (trial group) or without (control group) topical 0.1% pranoprofen. The PD and IOP were measured at different time points within 30 min after the completion of the femtosecond laser treatment. RESULTS: The comparisons of the two groups showed the PD of patients pretreated with 0.1% pranoprofen was significantly larger than that of the control only at 15 min after FLACS (P = 0.046), and there was no significant difference in IOP at any time point (P > 0.05). Neither the ratio of significant miosis (PD ≤ 5 mm) nor intraocular hypertension (IOP ≥30 mmHg) was significantly different between the control group (1.72%, 6.67%) and the trial group (1%, 4.17%) (P > 0.05). CONCLUSIONS: The PD and IOP of patients undergoing FLACS showed fluctuations within a small range. The rates of significant miosis and intraocular hypertension are very low, it is safe for surgeons to complete the follow-up procedures within 30 min after femtosecond laser treatment. Pretreatment with 0.1% pranoprofen exerted a slight, albeit significant prophylactic effect preventing pupil miosis. However, it provided only a limited benefit in patients undergoing FLACS without other complications.