Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults

骨骼肌毛细血管化程度低限制了老年人肌肉对阻力运动训练的适应

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作者:Tatiana Moro, Camille R Brightwell, Danielle E Phalen, Colleen F McKenna, Samantha J Lane, Craig Porter, Elena Volpi, Blake B Rasmussen, Christopher S Fry

Results

Basal capillarization (C:Fi; CFPE and LP-CF index) correlates with daily physical activity level (C:Fi, r = 0.57, p = 0.019; CFPE index, r = 0.55, p = 0.024; LC-PF index, r = 0.56, p = 0.022) and CFPE and LC-PF indices were also positively associated with oxidative capacity (respectively r = 0.45, p = 0.06; r = 0.67, p = 0.004). Following RET, subjects in the HIGH group underwent hypertrophy with significant improvements in muscle protein synthesis and muscle fiber CSA (p < 0.05). However, RET did not promote muscle hypertrophy in the LOW group, but RET significantly increased muscle capillary density (p < 0.05).

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