IL-17A, a possible biomarker for the evaluation of treatment response in Trypanosoma cruzi infected children: A 12-months follow-up study in Bolivia

IL-17A 是评估克氏锥虫感染儿童治疗反应的可能生物标志物：玻利维亚的一项为期 12 个月的随访研究

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作者：Clara Vásquez Velásquez,Graciela Russomando,Emilio E Espínola,Zunilda Sanchez,Kota Mochizuki,Yelin Roca,Jimmy Revollo,Angelica Guzman,Benjamín Quiroga,Susana Rios Morgan,Roberto Vargas Ortiz,Alberto Zambrana Ortega,Eida Espinoza,Juan Eiki Nishizawa,Mohamed Gomaa Kamel,Mihoko Kikuchi
期刊：PLoS Neglected Tropical Diseases影响因子：
时间：2019起止号：2019 Sep 25;13(9):e0007715.
doi：10.1371/journal.pntd.0007715研究方向： 信号转导

Background

The National Program for Chagas disease was implemented in Bolivia in 2006, and it greatly decreased the number of infections through vector control. Subsequently, a treatment regimen of benznidazole (BNZ) was started in seropositive school-age children living in certified vector control areas.

Conclusions

Plasma levels of IL-17A might be a bio-marker for detecting persistent infection of T. cruzi and its chronic inflammation.

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