Abstract
A new vision of personalized medicine or personalized healthcare has evolved as a consequence of remarkable recent advances in technologies that allow to look at individual variation across the entire human genome and to identify personal risk factors behind many diseases and responses to therapy. These advances have greatly increased our understanding of how interactions between the entire genome and nongenomic factors result in health and disease and in therapeutic response. The challenge is now to translate this knowledge into benefits for the individual patient. I expect the Journal of Personalized Medicine to become the premier venue for the rapid and freely accessible publication of high quality manuscripts dealing with this vision for scientists around the world. [...].