Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma

肠道微生物组指导肝细胞募集 MDSC 并促进胆管癌

阅读:8
作者:Qianfei Zhang, Chi Ma, Yi Duan, Bernd Heinrich, Umberto Rosato, Laurence P Diggs, Lichun Ma, Soumen Roy, Qiong Fu, Zachary J Brown, Simon Wabitsch, Vishal Thovarai, Jianyang Fu, Dechun Feng, Benjamin Ruf, Linda L Cui, Varun Subramanyam, Karen M Frank, Sophie Wang, David E Kleiner, Thomas Ritz, Chris

Significance

MDSCs have been shown to be induced by tumors and suppress antitumor immunity. Here we show that the gut microbiome can control accumulation of MDSCs in the liver in the context of a benign liver disease or colitis.See related commentary by Chagani and Kwong, p. 1014.This article is highlighted in the In This Issue feature, p. 995.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用;引用内容仅为补充信息,不代表本站立场。

2、若认为本页面引用内容涉及侵权,请及时与本站联系,我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容,需注明“来源:[生知库]”并获得授权;使用引用内容的,需自行联系原作者获得许可。

4、投稿及合作请联系:info@biocloudy.com。