Abstract
The aim of this research was to investigate dysregulated pivotal genes in individuals with lumbar disc herniation (LDH) to identify potential diagnostic biomarkers and treatment targets for LDH. Key aging-related genes in LDH were identified through multiple methods. Two dysregulated key genes (FPR1 and UCHL1) were finally identified, showing high diagnostic value in both training and external validation cohorts. Dysregulated expression of these hub genes established a detrimental cycle in LDH by promoting inflammatory response, immune infiltration, and aging progression. This highlights significant pathological alterations caused by these hub genes in LDH pathogenesis. The current study developed a novel genetic signature associated with aging that accurately diagnoses LDH while characterizing biological alterations in patients with this condition. And this genetic signature holds promise as an indicator to assist clinical decision-making. Moreover, identification of FPR1 and UCHL1 as pivotal genes presents potential prospects for targeted therapeutic interventions for LDH.