Abstract
Cellular protein compartmentalization is essential for function, yet the mechanisms directing proteins to their correct destinations remain unclear. Recently, Kilgore, Chinn, Mikhael, and Mitnikov et al. introduced ProtGPS, an artificial intelligence (AI) model that recognizes sequence-encoded localization patterns. ProtGPS predicts condensate-targeting sequences, facilitates peptide design, and identifies pathogenic mutations disrupting protein compartmentalization.