In utero exposure to cigarette smoke dysregulates human fetal ovarian developmental signalling

宫内接触香烟烟雾会导致人类胎儿卵巢发育信号失调

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作者:Paul A Fowler, Andrew J Childs, Frédérique Courant, Alasdair MacKenzie, Stewart M Rhind, Jean-Philippe Antignac, Bruno Le Bizec, Panagiotis Filis, Fergus Evans, Samantha Flannigan, Abha Maheshwari, Siladitya Bhattacharya, Ana Monteiro, Richard A Anderson, Peter J O'Shaughnessy

Methods

Ovary, liver and plasma samples were collected from electively terminated, normally progressing, second trimester human fetuses. Circulating fetal hormones, levels of 73 fetal ovarian transcripts, protein localization, density of oocytes/primordial follicles and levels of 16 polycyclic aromatic hydrocarbons (PAHs) in the fetal liver were determined. Main

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