Abstract
Multidrug-resistant (MDR) bacteria pose a growing threat to global health, prompting exploration of alternative therapies. This study uses bioinformatic modelling to assess ozone therapy as an adjunct treatment, analysing both linear and non-linear (chaotic) frameworks. Results suggest that ozone exerts bactericidal effects and modulates immune responses, partly through the production of 4-hydroxynonenal. Simulations indicate that ozone-induced adaptive chaos may enhance immune resilience and accelerate bacterial clearance compared to antibiotics alone. However, the findings are theoretical, and the short half-life of ozone limits direct impact, emphasizing the need for experimental validation. Ozone therapy shows promise, but its role in adaptive chaos requires further study to determine its clinical viability, despite a large number of reports showing an undisputable action of medical ozone against MDR bacteria.