Bile acids stimulate cholangiocyte fluid secretion by activation of transmembrane member 16A Cl- channels

胆汁酸通过激活跨膜成员 16A Cl- 通道刺激胆管细胞液分泌

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作者:Qin Li, Amal Dutta, Charles Kresge, Abhijit Bugde, Andrew P Feranchak

Conclusion

Bile acids stimulate Cl- secretion in mouse and human biliary cells through activation of membrane TMEM16A channels in a process regulated by extracellular ATP and [Ca2+ ]i . These studies suggest that TMEM16A channels may be targets to increase bile flow during cholestasis. (Hepatology 2018;68:187-199).

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