Abstract
Cortical neural responses can be modulated by various factors, such as stimulus inputs and the behavior state of the animal. Understanding the circuit mechanisms underlying modulations of network dynamics is important to understand the flexibility of circuit computations. Identifying the dynamical state of a network is an important first step to predict network responses to external stimulus and top-down modulatory inputs. Models in stable or unstable dynamical regimes require different analytic tools to estimate the network responses to inputs and the structure of neural variability. In this article, I review recent cortical models of state-dependent responses and their predictions about the underlying modulatory mechanisms.