Abstract
Giant cell tumors (GCTs) are rare, representing 4-5% of all bone tumors. Although uncommon in pregnancy, the literature showed the accelerated progression and recurrence of GCT in pregnancy; however, the tumor growth in pregnancy has not been clarified. We report a case of a 28-year-old woman in her first trimester presenting with an aggressive GCT, significantly affecting the patient's quality of life due to the debilitating nature of her symptoms. Considering the significant functional impairment and aggressive nature of the tumor, a multidisciplinary team opted for surgical intervention, entailing marginal resection and mega-prosthesis implantation. A multidisciplinary approach tailored to the patient's needs enabled successful surgical intervention and positive maternal and fetal outcomes. This case paves the way for the possibility that surgical management of GCTs can be safely performed during pregnancy, highlighting the challenges and critical importance of multidisciplinary care in rare tumor management during pregnancy through timely intervention.