Aim
The combination of tumor-targeting IL2- and TNF-based antibody-cytokine fusions has exhibited encouraging
Conclusion
Immunocompetent mouse tumor models may not be adequate enough to predict the search for more efficacious therapy regimens.
Methods
Mice receiving a single intratumoral injection of F8-IL2, F8-TNF or the combination were investigated for tumor-infiltrating leukocytes and rechallenged when cured.
Results
In three models, a proportion of treated animals could be cured, most probably by infiltrating NK and CD8+ T cells. Most of the cured mice did not acquire protective immunity when rechallenged with the same tumor cell line.