Allenyl Thianthrenium Salt: A Bench-Stable C(3) Synthon for Annulation and Cross-Coupling Reactions

烯丙基噻蒽鎓盐:一种可用于环化和交叉偶联反应的稳定C(3)合成子

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Abstract

Herein, we report the first bench-stable and nonhygroscopic monosubstituted allenyl sulfonium salt (ATT) synthesized from thianthrene and propargyl alcohol. We demonstrate its use in annulation chemistry to synthesize heterocycles, such as 2-hydroxy morpholine, 2-methyl quinoxalines, and benzodioxepinone derivatives, with an exocyclic double bond. The reagent is the first allenyl sulfonium salt that can undergo palladium-catalyzed cross-coupling reactions to form a C(sp(2))-C(sp(2)) bond via Suzuki coupling and a C(sp(3))-C(sp(2)) bond formation via reductive coupling.

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