A concise method for fully automated radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM via Cu-mediated (18)F-fluorination of organoboranes

A modified alcohol-enhanced (18)F-fluorodeboronation has been developed for the radiosyntheses of [(18)F]JNJ-46356479 and [(18)F]FITM. Unlike the [(18)F]KF/K(222) approach, this method tolerates the presence of sensitive heterocycles in Bpin precursors 4 and 8 allowing a one-step (18)F-fluorodeboronation on the fully automated TRACERlab™ FX(FN) platform.