Metal-free synthesis of C2-quaternary indolinones by (NH(4))(2)S(2)O(8) mediated oxidative dearomatization of indoles

利用(NH(4))2S(2)O(8)介导的吲哚氧化脱芳构化反应,实现C2-季碳吲哚啉酮的无金属合成

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Abstract

An efficient metal-free, (NH(4))(2)S(2)O(8) mediated oxidative dearomatization of indoles for the construction of C2-quaternary indolinones was disclosed. A series of C2-quaternary indolinones derivatives with good functional group tolerance were obtained in moderate to excellent yields. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C2 position of indoles. This catalytic approach represents a step-economic and convenient strategy for the oxidative dearomatization of indoles.

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