Twofold unsymmetrical C-H functionalization of PyrDipSi-substituted arenes: a general method for the synthesis of substituted meta-halophenols

PyrDipSi取代芳烃的双重不对称CH官能化:一种合成取代间卤代苯酚的通用方法

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Abstract

Two-fold unsymmetrical functionalization of arenes, which includes sequential halogenation/oxygenation reactions, has been developed. This transformation allows for a general and efficient synthesis of substituted meta-halophenols from simple aryl iodides. Importantly, the PyrDipSi (2-diisopropylsilylpyrimidine) group can be easily removed or efficiently converted into valuable functionalities.

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