Iron-Catalyzed Glycal cis-Aminoacyloxylation for 2-Amino Saccharide Synthesis

铁催化糖苷顺式氨基酰氧基化反应合成2-氨基糖

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Abstract

We report here a new catalytic and exclusively 1,2-cis-selective glycal aminoacyloxylation method for 2-amino saccharide synthesis. This iron-catalyzed glycosylation is effective for a wide variety of glycosyl donors with consistently high stereoselectivity and excellent functional-group compatibility, which facilitates late-stage amino group incorporation for complex-carbohydrate synthesis.

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