The synthesis of C-3β functionalized indoles via a hydroboration/Suzuki-Miyaura coupling sequence

通过氢硼化/Suzuki-Miyaura偶联反应合成C-3β功能化的吲哚

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Abstract

A method for the functionalization of C-3β of vinyl indoles is described. The procedure involves a hydroboration, followed by a Suxuki-Miyaura cross-coupling with the intermediate alkyl borane. Triflates, bromides, and iodides are suitable coupling partners, allowing access to a variety of elaborated indole compounds.

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