Abstract
Reductive late-stage functionalization of gibberellic acid is reported using three fluoroarylborane Lewis acids; (B(C(6)F(5))(3), B(3,5-C(6)H(3)(CF(3))(2)), and B(2,4,6-C(6)H(2)F(3))(3)) in combination with a tertiary silane and a borane (HBCat) reductant. In each case, C-O bond activation occurs, and different products are obtained depending on the reductant and catalyst employed.