Suzuki-Miyaura Cross-Coupling of Benzylic Bromides Under Microwave Conditions

微波条件下苄基溴化物的铃木-宫浦交叉偶联反应

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Abstract

A procedure for benzylic Suzuki-Miyaura cross-coupling under microwave conditions has been developed. These conditions allowed for heterocyclic compounds to be coupled. Optimum conditions found were Pd(OAc)(2), JohnPhos as the catalyst and ligand, potassium carbonate as base, and DMF as the solvent. Using these conditions, a library of structurally diverse compounds was synthesized.

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