Abstract
We report structural and computational studies of three α-aminophosphonates 4-XC(6)H(4)-NH-CH(4-BrC(6)H(4))-P(O)(OiPr)(2), namely diisopropyl((4-bromophenyl)(phenylamino)methyl)phosphonate (X = H, 1), diisopropyl((4-bromophenyl)((4-bromophenyl)amino)methyl)phosphonate (X = Br, 2) and diisopropyl((4-bromophenyl)((4-methoxyphenyl)amino)methyl)phosphonate (X = MeO, 3). The structures of 1-3 were fully confirmed by means of the (31)P{(1)H} and (1)H NMR spectroscopy. Crystal structures of 2 and 3 are isostructural and each contain two independent molecules in the asymmetric unit cell. Energy frameworks have been calculated to analyze the overall crystal packing of 1-3. The DFT calculations were performed to verify the structures of 1-3 as well as their electronic and optical properties. Molecular docking was applied to examine the influence of both the (S)- and (R)-enantiomers of 1-3 on a series of the SARS-CoV-2 proteins.